NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC₅₀ values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

R-enantiomer also available.

Product Specifications

Molecular Weight

393.45

Formula

C₂₄H₂₄FNO₃

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine

CAS Number

405225-21-0

PubChem ID

5311283

InChI Key

FDORQEIHOKEJNX-UHFFFAOYSA-N

SMILES

FC1=CC=C(C(OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.93	10
	Ethanol	1.97	5 with gentle warming

Preparing Stock Solutions for NFPS

The following data is based on the product molecular weight 393.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.42 mL	127.08 mL	254.16 mL
0.5 mM	5.08 mL	25.42 mL	50.83 mL
1 mM	2.54 mL	12.71 mL	25.42 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Harsing Jr. The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav.
Mallorga Pharmacology and expression analysis of glycine transporter GlyT1 with [³H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 2003 PMID: 12941372
Bergeron Modulation of N-MthD.-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA

NFPS

Tocris Bioscience, part of Bio-Techne | Catalog # 2789

Key Product Details

Description

Alternative Names

View all Glycine Transporter Inhibitors »

Product Description