NFAT Inhibitor

Name: NFAT Inhibitor
Brand: Tocris Bioscience
SKU: 3930

Tocris Bioscience, part of Bio-Techne | Catalog # 3930

Citations (12)

COA / SDS

Inhibitor of calcineurin-mediated NFAT activation

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Technical Data
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Product Description
Product Specifications
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Calculators
Background References
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Specific Notices

Key Product Details

Description

Inhibitor of calcineurin-mediated NFAT activation

Alternative Names

VIVIT peptide

View all NFAT Inhibitors »

Product Description

NFAT Inhibitor is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Product Specifications

Molecular Weight

1683.94

Formula

C₇₅H₁₁₈N₂₀O₂₂S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

249537-73-3

PubChem ID

16135717

InChI Key

QPMHUXBSHGAVGD-MCDIZDEASA-N

SMILES

[H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Nagamoto-Combs and Combs Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci. 2010 PMID: 20631193
Roehrl Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.
Aramburu Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 1999 PMID: 10497131