NESS 0327
Tocris Bioscience, part of Bio-Techne | Catalog # 5746
Ultra-high affinity and selective CB1 antagonist
Key Product Details
Description
Ultra-high affinity and selective CB1 antagonist
Product Description
NESS 0327 is an ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits >60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.Product Specifications
Molecular Weight
489.82
Formula
C24H23Cl3N4O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
CAS Number
494844-07-4
PubChem ID
10435654
InChI Key
NCXBPZJQQSNIRA-UHFFFAOYSA-N
SMILES
O=C(NN1CCCCC1)C2=NN(C3=CC=C(Cl)C=C3Cl)C4=C2CCCC5=C4C=CC(Cl)=C5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.8 | 20 |
Preparing Stock Solutions
for NESS 0327
The following data is based on the product molecular weight 489.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.21 mL | 51.04 mL | 102.08 mL |
| 1 mM | 2.04 mL | 10.21 mL | 20.42 mL |
| 2 mM | 1.02 mL | 5.10 mL | 10.21 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ruiu Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor. J.Pharmacol.Exp.Ther. 2003 PMID: 12663689
Product Specific Notices for NESS 0327
For research use only
Loading...
Loading...