Nemonapride
Tocris Bioscience, part of Bio-Techne | Catalog # 1746
Highly potent D2-like antagonist; also 5-HT1A agonist
Key Product Details
Description
Highly potent D2-like antagonist; also 5-HT1A agonist
Alternative Names
YM 09151,YM 09151-2
Product Description
Nemonapride is a highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.Product Specifications
Molecular Weight
387.91
Formula
C21H26ClN3O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
CAS Number
75272-39-8
PubChem ID
76968489
InChI Key
QCYCDKUNJFKYEI-ZVWWNKPMSA-N
SMILES
O=C(C3=C(OC)C=C(NC)C(Cl)=C3)N[C@@H]1CCN(CC2=CC=CC=C2)[C@@H]1C.O=C(C6=C(OC)C=C(NC)C(Cl)=C6)N[C@H]4CCN(CC5=CC=CC=C5)[C@H]4C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.7 | 25 | |
| Ethanol | 7.76 | 20 |
Preparing Stock Solutions
for Nemonapride
The following data is based on the product molecular weight 387.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.31 mL | 51.56 mL | 103.12 mL |
| 1.25 mM | 2.06 mL | 10.31 mL | 20.62 mL |
| 2.5 mM | 1.03 mL | 5.16 mL | 10.31 mL |
| 12.5 mM | 0.21 mL | 1.03 mL | 2.06 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Terai Selective binding of YM-09151-2, a new potent neuroleptic, to D2-DArgic receptors. Jpn.J.Pharmacol. 1983 PMID: 6138453
- Ujike [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes. Neuroreport 1996 PMID: 8804051
- Assie 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and cloz. Eur.J.Pharmacol. 1997 PMID: 9369342
Product Specific Notices for Nemonapride
For research use only
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