Nefiracetam

Name: Nefiracetam
Brand: Tocris Bioscience
SKU: 2851

Tocris Bioscience, part of Bio-Techne | Catalog # 2851

Citations (9)

COA / SDS

Cognitive enhancer

Key Product Details

Description:	Cognitive enhancer
Alternative Names:	DM 9384
Chemical Name:	N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Purity:	≥99% (HPLC)
Molecular Weight:	246.3

View Full Technical Details for Nefiracetam

Technical Data
Citations

Biological Activity for Nefiracetam

Nefiracetam is a cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.

Technical Data for Nefiracetam

M. Wt	246.3
Formula	C₁₄H₁₈N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	77191-36-7
PubChem ID	71157
InChi Key	NGHTXZCKLWZPGK-UHFFFAOYSA-N
Smiles	O=C(NC2=C(C)C=CC=C2C)CN1C(CCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nefiracetam

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.63	100
	ethanol	24.63	100

Preparing Stock Solutions for Nefiracetam

The following data is based on the product molecular weight 246.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.06 mL	20.30 mL	40.60 mL
5 mM	0.81 mL	4.06 mL	8.12 mL
10 mM	0.41 mL	2.03 mL	4.06 mL
50 mM	0.08 mL	0.41 mL	0.81 mL

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Reconstitution Calculator

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References for Nefiracetam

References are publications that support the biological activity of the product.

Ueda The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 2004 PMID: 14718588
Kitano Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 2005 PMID: 16190926
Narahashi Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 2004 PMID: 15516710