Nebivolol hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3517
Highly selective β1-adrenoceptor antagonist
Key Product Details
Description
Highly selective β1-adrenoceptor antagonist
Product Description
Nebivolol hydrochloride is a highly selective β1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1, 5-HT1A, β2, 5-HT2, α1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.Product Specifications
Molecular Weight
441.90
Formula
C22H25F2NO4.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
CAS Number
152520-56-4
PubChem ID
11812257
InChI Key
JWEXHQAEWHKGCW-VCVZPGOSSA-N
SMILES
FC(C=C4)=CC3=C4O[C@@](CC3)([H])[C@H](O)CNC[C@@H](O)[C@]2([H])CCC1=CC(F)=CC=C1O2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.19 | 100 | |
| Ethanol | 4.42 | 10 |
Preparing Stock Solutions
for Nebivolol hydrochloride
The following data is based on the product molecular weight 441.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.31 mL | 22.63 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.53 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Georgescu Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. Pharmacology 2008 PMID: 17952013
- Erickson The beta-blocker nebi. Is a GRK/ beta-arrestin biased agonist. PLoS One 2013 PMID: 23977191
- Pauwels The receptor binding profile of the new antihypertensive agent nebi. and its stereoisomers compared with various β-adrenergic blockers. Mol.Pharmacol. 1988 PMID: 2462161
Product Specific Notices for Nebivolol hydrochloride
For research use only
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