NCT 02
Tocris Bioscience, part of Bio-Techne | Catalog # 7551
Molecular glue; induces degradation of CCNK and CDK12
Key Product Details
Description
Molecular glue; induces degradation of CCNK and CDK12
Product Description
NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC50 ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.Product Specifications
Molecular Weight
312.39
Formula
C17H16N2O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide
CAS Number
790245-61-3
PubChem ID
2501755
InChI Key
IELCYEUTXLYDOV-UHFFFAOYSA-N
SMILES
CC1=CN=C(S1)NC(CC2=COC3=C2C=C4CCCC4=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.24 | 100 |
Preparing Stock Solutions
for NCT 02
The following data is based on the product molecular weight 312.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.20 mL | 16.01 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.20 mL | 6.40 mL |
| 10 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dieter Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021 PMID: 34289372
Product Specific Notices for NCT 02
For research use only
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