NBMPR
Tocris Bioscience, part of Bio-Techne | Catalog # 2924
Equilibrative nucleoside transporter 1 (ENT1) inhibitor
Key Product Details
Description
Equilibrative nucleoside transporter 1 (ENT1) inhibitor
Product Description
NBMPR is an equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).Product Specifications
Molecular Weight
419.41
Formula
C17H17N5O6S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
CAS Number
38048-32-7
PubChem ID
65407
InChI Key
DYCJFJRCWPVDHY-LSCFUAHRSA-N
SMILES
OC[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3SCC4=CC=C([N+]([O-])=O)C=C4)[C@H](O)[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.94 | 100 |
Preparing Stock Solutions
for NBMPR
The following data is based on the product molecular weight 419.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tsujie Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 PMID: 17695509
- Lin and Buolamwini Synthesis and flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 2007 PMID: 17636949
- Ward Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 2000 PMID: 10722669
Product Specific Notices for NBMPR
For research use only
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