NBC 6
Tocris Bioscience, part of Bio-Techne | Catalog # 6925
NLRP3 inflammasome inhibitor
Discontinued Product
6925 has been discontinued.
View all Inflammasomes Inhibitors products.
Product Description
NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).Licensing Information
Sold under license from the University of Manchester.Product Specifications
Molecular Weight
409.50
Formula
C18H16BCl3N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
CAS Number
2068818-02-8
PubChem ID
145237739
InChI Key
VKECODDKRKQJNM-UHFFFAOYSA-N
SMILES
CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.95 | 100 | |
| Ethanol | 2.05 | 5 |
Preparing Stock Solutions
for NBC 6
The following data is based on the product molecular weight 409.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Baldwin Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 2017 PMID: 28943355
Product Specific Notices for NBC 6
For research use only
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