N^α-Methylhistamine dihydrochloride

Name: N α -Methylhistamine dihydrochloride
Brand: Tocris Bioscience
SKU: 0573

Tocris Bioscience, part of Bio-Techne | Catalog # 0573

COA / SDS

Non-selective H3 agonist

Discontinued Product

0573 has been discontinued. View all Histamine H3 Receptor Agonists products.

Key Product Details

Description:	Non-selective H₃ agonist
Chemical Name:	N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Molecular Weight:	198.09

View Full Technical Details for N^α-Methylhistamine dihydrochloride

Technical Data
Citations

Biological Activity

N^α-Methylhistamine dihydrochloride is a potent histamine agonist, particularly at H₃ receptors (potency relative to histamine is 81, 185, and 270% at H₁, H₂ and H₃ respectively). Also displays agonist properties at H₄ receptors to which it binds with moderate affinity (K_i = 23 nM).

Technical Data

M. Wt	198.09
Formula	C₆H₁₁N₃.2HCl
Storage	Desiccate at RT
CAS Number	16503-22-3
PubChem ID	16078977
InChi Key	AYUQICXJAMPXPF-UHFFFAOYSA-N
Smiles	Cl.Cl.CNCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Schwartz A third histamine receptor subtype - characterization, localization and functions of the H₃-receptor. Agents Actions 1990 PMID: 1695431
Zweig Characterization of digitonin-solubilized bovine brain H₃ histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 1992 PMID: 1328529
Hill Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693

N^α-Methylhistamine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0573

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected

Nα-Methylhistamine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0573

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

N^α-Methylhistamine dihydrochloride