N-Formyl-Met-Leu-Phe
Tocris Bioscience, part of Bio-Techne | Catalog # 1921
Endogenous FPR1 agonist
Key Product Details
Description
Endogenous FPR1 agonist
Alternative Names
fMLP
Product Description
N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.Product Specifications
Molecular Weight
437.55
Formula
C21H31N3O5S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
59880-97-6
PubChem ID
443295
InChI Key
PRQROPMIIGLWRP-BZSNNMDCSA-N
SMILES
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 4mg/ml in DMSO |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Mills Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 2000 PMID: 10960471
- Spilberg Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 1984 PMID: 6325345
- Kreutzer Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1978 PMID: 45788
Product Specific Notices for N-Formyl-Met-Leu-Phe
For research use only
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