N-Formyl-Met-Leu-Phe

Name: N -Formyl-Met-Leu-Phe
Brand: Tocris Bioscience
SKU: 1921

Tocris Bioscience, part of Bio-Techne | Catalog # 1921

Citations (12)

COA / SDS

Endogenous FPR1 agonist

Key Product Details

Description:	Endogenous FPR1 agonist
Alternative Names:	fMLP
Purity:	≥95% (HPLC)
Molecular Weight:	437.55

View Full Technical Details for N-Formyl-Met-Leu-Phe

Technical Data
Citations

Biological Activity for N-Formyl-Met-Leu-Phe

N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (K_i = 38 nM). Stimulates aggregation of leukocytes.

Technical Data for N-Formyl-Met-Leu-Phe

M. Wt	437.55
Formula	C₂₁H₃₁N₃O₅S
Single Letter Sequence	MLF (Modifications: Met-1 = N-formyl-Met)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	59880-97-6
PubChem ID	443295
InChi Key	PRQROPMIIGLWRP-BZSNNMDCSA-N
Smiles	CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for N-Formyl-Met-Leu-Phe

Solubility

Soluble to 4mg/ml in DMSO

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References for N-Formyl-Met-Leu-Phe

References are publications that support the biological activity of the product.

Mills Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 2000 PMID: 10960471
Spilberg Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 1984 PMID: 6325345
Kreutzer Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1978 PMID: 45788