MSOP
Tocris Bioscience, part of Bio-Techne | Catalog # 0803
Specific group III mGlu antagonist
Key Product Details
Description
Specific group III mGlu antagonist
Product Description
MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.Product Specifications
Molecular Weight
199.10
Formula
C4H10NO6P
Storage
Store at RT
Chemical Name
(RS)-α-Methylserine-O-phosphate
CAS Number
66515-29-5
PubChem ID
3964633
InChI Key
GSFCOAGADOGIGE-UHFFFAOYSA-N
SMILES
NC(COP(O)(O)=O)(C)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.91 | 100 |
Preparing Stock Solutions
for MSOP
The following data is based on the product molecular weight 199.10
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.02 mL | 25.11 mL | 50.23 mL |
| 5 mM | 1.00 mL | 5.02 mL | 10.05 mL |
| 10 mM | 0.50 mL | 2.51 mL | 5.02 mL |
| 50 mM | 0.10 mL | 0.50 mL | 1.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jane Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon
- Thomas Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr.
- Thomas α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 1996 PMID: 8887973
Product Specific Notices for MSOP
For research use only
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