MSC 4381
Tocris Bioscience, part of Bio-Techne | Catalog # 8008
Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
Key Product Details
Description
Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
Product Description
MSC 4381 is a potent and selective monocarboxylate transporter 4 (MCT4) inhibitor (IC50 = 77 nM; Ki = 11 nM). Inhibits lactate efflux in MDA-MB-231 cells (IC50 = 1 nM) and reduces viability of cells expressing high levels of MCT4.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 4381 probe summary on the SGC website.Product Specifications
Molecular Weight
537.97
Formula
C26H20ClN3O6S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid
CAS Number
2445185-57-7
PubChem ID
150189198
InChI Key
FNBUZGRPJLEIMO-UHFFFAOYSA-N
SMILES
O=C(C1=NC=C(C(OC)=C1)C#CC2=CC(Cl)=CC=C2NS(=O)(C3=CC=C(C4=CC=CN=C43)OCC)=O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.9 | 50 |
Preparing Stock Solutions
for MSC 4381
The following data is based on the product molecular weight 537.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.72 mL | 18.59 mL | 37.18 mL |
| 2.5 mM | 0.74 mL | 3.72 mL | 7.44 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 25 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for MSC 4381
For research use only
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