MSC 1186
Tocris Bioscience, part of Bio-Techne | Catalog # 7927
Potent and selective SRPK family inhibitor
Key Product Details
Description
Potent and selective SRPK family inhibitor
Product Description
MSC1186 is a potent and selective inhibitor of serine arginine protein kinases (SRPK) 3, 1 and 2 (IC50 values are 0.6 nM, 3 nM and 81 nM respectively in biochemical assay; EC50 values in NanoBRETassay are 40 nM, 98 nM and 149 nM, respectively). Shows no activity at CLK and DYRK families (IC50 >10 μM).Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 1186 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MSC 1186 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
461.90
Formula
C19H17ClFN7O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide
CAS Number
2871698-23-4
PubChem ID
162368309
InChI Key
WBFJDKLBAAHKIL-UHFFFAOYSA-N
SMILES
O=S(N(C)C1=NC=CC=C1CNC2=NC(C3=NC4=C(N3)C(F)=C(Cl)C=C4)=NC=C2)(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.09 | 50 |
Preparing Stock Solutions
for MSC 1186
The following data is based on the product molecular weight 461.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.33 mL | 21.65 mL | 43.30 mL |
| 2.5 mM | 0.87 mL | 4.33 mL | 8.66 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 25 mM | 0.09 mL | 0.43 mL | 0.87 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schröder MSC-1186, a highly selective pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core. J.Med.Chem. 2023 PMID: 36516476
Product Specific Notices for MSC 1186
For research use only
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