MS 15203

Name: MS 15203
Brand: Tocris Bioscience
SKU: 6299

Tocris Bioscience, part of Bio-Techne | Catalog # 6299

Citations (1)

COA / SDS

Potent and selective GPR171 partial agonist

Discontinued Product

6299 has been discontinued. View all GPR171 Agonists products.

Key Product Details

Description:	Potent and selective GPR171 partial agonist
Chemical Name:	5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	249.22

View Full Technical Details for MS 15203

Technical Data
Citations

Biological Activity for MS 15203

MS 15203 is a potent and selective GPR171 partial agonist (EC₅₀ = 90 nM; 28% inhibition of Forskolin activated adenylyl cyclase activity in rat hypothalamic membranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.

Compound Libraries for MS 15203

MS 15203 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MS 15203

M. Wt	249.22
Formula	C₁₂H₁₁NO₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	73912-52-4
PubChem ID	773544
InChi Key	NVOBVSWSDYFEMR-UHFFFAOYSA-N
Smiles	CC(C(NC1=CC(C(O)=O)=CC(C(O)=O)=C1)=O)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MS 15203

References are publications that support the biological activity of the product.

Wardman Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake Sci.Signal. 2016 PMID: 27245612