MS 143

Name: MS 143
Brand: Tocris Bioscience
SKU: 8081

Tocris Bioscience, part of Bio-Techne | Catalog # 8081

COA / SDS

AKT kinase Degrader (PROTAC®)

Key Product Details

Description:	AKT kinase Degrader (PROTAC^®)
Chemical Name:	4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	1121.89

View Full Technical Details for MS 143

Technical Data
Citations

Biological Activity for MS 143

MS 143 is a potent and selective protein kinase B (AKT) Degrader (PROTAC^®) (DC₅₀ = 46 nM, D_max = 100 % at 24h in PC3 cells). MS 143 suppresses growth in prostate cancer PC3 cells; suppresses tumor growth and reduces AKT protein levels in a mouse PC3 cell xenograft model.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 143

M. Wt	1121.89
Formula	C₅₉H₈₁ClN₁₂O₆S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2376137-41-4
InChi Key	DESJGFOSPPNXOH-XUXNHVGISA-N
Smiles	O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCCCC(N(CC4)CCN4CC[C@@H](C5=CC=C(C=C5)Cl)NC(C6(CCN(CC6)C7=C8C(NC=C8)=NC=N7)N)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 143

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	112.19	100

Preparing Stock Solutions for MS 143

The following data is based on the product molecular weight 1121.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.89 mL	4.46 mL	8.91 mL
5 mM	0.18 mL	0.89 mL	1.78 mL
10 mM	0.09 mL	0.45 mL	0.89 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

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References for MS 143

References are publications that support the biological activity of the product.

Yu Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure-activity relationship studies. J.Med.Chem. 2022 PMID: 35119851