MRT 68601 hydrochloride

Name: MRT 68601 hydrochloride
Brand: Tocris Bioscience
SKU: 5067

Tocris Bioscience, part of Bio-Techne | Catalog # 5067

Citations (5)

COA / SDS

Potent TBK inhibitor

Key Product Details

Description:	Potent TBK inhibitor
Chemical Name:	N-[3-[[5-Cyclopropyl-2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	487.04

View Full Technical Details for MRT 68601 hydrochloride

Technical Data
Citations

Biological Activity for MRT 68601 hydrochloride

MRT 68601 hydrochloride is a potent TBK1 (TANK-binding kinase-1) inhibitor (IC₅₀ = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.

Technical Data for MRT 68601 hydrochloride

M. Wt	487.04
Formula	C₂₅H₃₄N₆O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962928-25-1
PubChem ID	121513855
InChi Key	BOBHGYDEKISHIZ-UHFFFAOYSA-N
Smiles	O=C(C1CCC1)NCCCNC2=C(C3CC3)C=NC(NC4=CC=C(N5CCOCC5)C=C4)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRT 68601 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	48.7	100
	DMSO	48.7	100

Preparing Stock Solutions for MRT 68601 hydrochloride

The following data is based on the product molecular weight 487.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.27 mL	20.53 mL
5 mM	0.41 mL	2.05 mL	4.11 mL
10 mM	0.21 mL	1.03 mL	2.05 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for MRT 68601 hydrochloride

References are publications that support the biological activity of the product.

McIver Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 2012 PMID: 23099093
Newman TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 2012 PMID: 23209807