MRS 2768 tetrasodium salt

Name: MRS 2768 tetrasodium salt
Brand: Tocris Bioscience
SKU: 3884

Tocris Bioscience, part of Bio-Techne | Catalog # 3884

Citations (5)

COA / SDS

Selective P2Y2 agonist

Key Product Details

Description:	Selective P2Y₂ agonist
Chemical Name:	Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	728.14

View Full Technical Details for MRS 2768 tetrasodium salt

Technical Data
Citations

Biological Activity for MRS 2768 tetrasodium salt

MRS 2768 tetrasodium salt is a selective P2Y₂ agonist (EC₅₀ = 1.89 μM). Displays no affinity for human P2Y₄ or P2Y₆ receptors. In a mouse model of myocardial infarction, pre-treatment with MRS 2768 protects cardiocytes and heart tissue from ischemic damage, and reduces circulating levels of TNF-α.

Technical Data for MRS 2768 tetrasodium salt

M. Wt	728.14
Formula	C₁₅H₁₆N₂O₁₈P₄Na₄
Storage	Store at -80°C
Purity	≥98% (HPLC)
CAS Number	2567869-47-8
PubChem ID	90488893
InChi Key	ASYFBNZFGLWLNC-YYXHNCPRSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC1=CC=CC=C1)N1C=CC(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2768 tetrasodium salt

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for MRS 2768 tetrasodium salt

References are publications that support the biological activity of the product.

Hochhauser P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo. Purinergic Signal. 2013 PMID: 23828651
Ko Synthesis and potency of novel uracil nucleotides and derivatives as P2Y₂ and P2Y₆ receptor agonists. Bioorg.Med.Chem. 2008 PMID: 18514530