MRS 2179 tetrasodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 0900
Selective P2Y1 antagonist
Product Description
MRS 2179 tetrasodium salt is a competitive antagonist at P2Y1 receptors (KB = 100 nM). Selective over P2X1 (IC50 = 1.15 μM), P2X3 (IC50 = 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. Inhibits the upregulation of NTPDase1 by ATPγS.Product Specifications
Molecular Weight
513.16
Formula
C11H13N5O9P2Na4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt
CAS Number
1454889-37-2
PubChem ID
90479745
InChI Key
XLPQPYQWGFCKEY-IDAKGYGSSA-J
SMILES
[Na+].[Na+].[Na+].[Na+].CNC1=NC=NC2=C1N=CN2[C@@H]1C[C@H](OP([O-])([O-])=O)[C@@H](COP([O-])([O-])=O)O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.66 | 50 |
Preparing Stock Solutions
for MRS 2179 tetrasodium salt
The following data is based on the product molecular weight 513.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.90 mL | 19.49 mL | 38.97 mL |
| 2.5 mM | 0.78 mL | 3.90 mL | 7.79 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.90 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nandanan Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J.Med.Chem. 1999 PMID: 10229631
- Brown Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev.Res. 2000 PMID: 22791931
- Lu Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
- Nandanan Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. J.Med.Chem. 2000 PMID: 10715151
- Boyer Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br.J.Pharmacol. 1998 PMID: 9630335
Product Specific Notices for MRS 2179 tetrasodium salt
For research use only
Loading...
Loading...
Loading...