MRS 2179 tetrasodium salt

Name: MRS 2179 tetrasodium salt
Brand: Tocris Bioscience
SKU: 0900
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0900

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Citations (36)

COA / SDS

Selective P2Y1 antagonist

Key Product Details

Description:	Selective P2Y₁ antagonist
Chemical Name:	2'-Deoxy-N⁶-methyladenosine 3',5'-bisphosphate tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	513.16

View Full Technical Details for MRS 2179 tetrasodium salt

Technical Data
Citations / Reviews (1)

Biological Activity for MRS 2179 tetrasodium salt

MRS 2179 tetrasodium salt is a competitive antagonist at P2Y₁ receptors (K_B = 100 nM). Selective over P2X₁ (IC₅₀ = 1.15 μM), P2X₃ (IC₅₀ = 12.9 μM), P2X₂, P2X₄, P2Y₂, P2Y₄ and P2Y₆ receptors. Inhibits the upregulation of NTPDase1 by ATPγS.

Technical Data for MRS 2179 tetrasodium salt

M. Wt	513.16
Formula	C₁₁H₁₃N₅O₉P₂Na₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1454889-37-2
PubChem ID	90479745
InChi Key	XLPQPYQWGFCKEY-IDAKGYGSSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].CNC1=NC=NC2=C1N=CN2[C@@H]1C[C@H](OP([O-])([O-])=O)[C@@H](COP([O-])([O-])=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2179 tetrasodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	25.66	50

Preparing Stock Solutions for MRS 2179 tetrasodium salt

The following data is based on the product molecular weight 513.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.90 mL	19.49 mL	38.97 mL
2.5 mM	0.78 mL	3.90 mL	7.79 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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Reconstitution Calculator

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References for MRS 2179 tetrasodium salt

References are publications that support the biological activity of the product.

Nandanan Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y₁ receptor antagonists and partial agonists. J.Med.Chem. 1999 PMID: 10229631
Brown Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev.Res. 2000 PMID: 22791931
Lu Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17626796
Nandanan Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y₁ receptor ligands. J.Med.Chem. 2000 PMID: 10715151
Boyer Competitive and selective antagonism of P2Y₁ receptors by N⁶-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br.J.Pharmacol. 1998 PMID: 9630335