MRS 1220
Tocris Bioscience, part of Bio-Techne | Catalog # 1217
Highly potent and selective hA3 antagonist
Key Product Details
Description
Highly potent and selective hA3 antagonist
Product Description
MRS 1220 is a potent and highly selective antagonist at the human A3 adenosine receptor (Ki values are 0.65, 305, and 52 nM at hA3, rA1 and rA2A respectively. Displays an IC50 value > 1 μM for inhibition of binding to rat A3 receptors).Licensing Information
Sold with the permission of the NIH, US Patent 60/029,855Product Specifications
Molecular Weight
403.83
Formula
C21H14ClN5O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[9-Chloro-2-(2-furanyl)[1,2,4]-triazolo[1,5-c]quinazolin-5-yl]benzene acetamide
CAS Number
183721-15-5
PubChem ID
393595
InChI Key
TWWFAXQOKNBUCR-UHFFFAOYSA-N
SMILES
ClC1=CC=C2N=C(NC(=O)CC3=CC=CC=C3)N3N=C(N=C3C2=C1)C1=CC=CO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.08 | 20 with gentle warming |
Preparing Stock Solutions
for MRS 1220
The following data is based on the product molecular weight 403.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.38 mL | 61.91 mL | 123.81 mL |
| 1 mM | 2.48 mL | 12.38 mL | 24.76 mL |
| 2 mM | 1.24 mL | 6.19 mL | 12.38 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kim Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) are selective for the human A3 receptor subtype. J.Med.Chem. 1996 PMID: 8863790
- Kim Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. J.Med.Chem. 1998 PMID: 9667972
- Jacobson Pharmacological characterization of novel A3 adenosine receptor selective antagonists. Neuropharmacology 1997 PMID: 9364471
Product Specific Notices for MRS 1220
For research use only
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