Mps1-IN-1 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5142
Selective Mps1 kinase inhibitor
Discontinued Product
5142 has been discontinued.
View all TTK/Mps1 Kinase Inhibitors products.
Key Product Details
Description
Selective Mps1 kinase inhibitor
Product Description
Mps1-IN-1 dihydrochloride is a selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
608.58
Formula
C28H33N5O4S.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride
CAS Number
1883548-93-3
PubChem ID
91691119
InChI Key
HFJLUXGXTPNYTQ-UHFFFAOYSA-N
SMILES
CC(C)S(C(C=CC=C3)=C3NC1=CC(NC4=C(OC)C=C(N5CCC(O)CC5)C=C4)=NC2=C1C=CN2)(=O)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 60.86 | 100 | |
| DMSO | 60.86 | 100 |
Preparing Stock Solutions
for Mps1-IN-1 dihydrochloride
The following data is based on the product molecular weight 608.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.22 mL | 16.43 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.29 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miduturu High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 2011 PMID: 21802008
- Lan and Cleveland A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 2010 PMID: 20624898
- Kwiatkowski Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 2010 PMID: 20383151
Product Specific Notices for Mps1-IN-1 dihydrochloride
For research use only
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