MP A08

Name: MP A08
Brand: Tocris Bioscience
SKU: 5803

Tocris Bioscience, part of Bio-Techne | Catalog # 5803

Citations (7)

COA / SDS

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Discontinued Product

5803 has been discontinued. View all Sphingosine Kinase Inhibitors products.

Key Product Details

Description:	Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Alternative Names:	NSC 122314
Chemical Name:	4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
Molecular Weight:	519.64

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Technical Data
Citations

Biological Activity for MP A08

MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (K_i values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Technical Data for MP A08

M. Wt	519.64
Formula	C₂₇H₂₅N₃O₄S₂
Storage	Store at -20°C
CAS Number	219832-49-2
PubChem ID	420266
InChi Key	FLDBNMYJUMAXDQ-UHFFFAOYSA-N
Smiles	O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MP A08

References are publications that support the biological activity of the product.

Pitman A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 2015 PMID: 25788259

MP A08

Tocris Bioscience, part of Bio-Techne | Catalog # 5803

Key Product Details

Biological Activity for MP A08

Technical Data for MP A08

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for MP A08

Product Documents for MP A08

COA

Certificate of Analysis

SDS

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