Monastrol
Tocris Bioscience, part of Bio-Techne | Catalog # 1305
Selective inhibitor of mitotic kinesin Eg5
Key Product Details
Description
Selective inhibitor of mitotic kinesin Eg5
Product Description
Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).Licensing Information
Sold with the permission of Harvard UniversityProduct Specifications
Molecular Weight
292.35
Formula
C14H16N2O3S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
CAS Number
254753-54-3
PubChem ID
5353454
InChI Key
UAIYNMRLUHHRMF-AATRIKPKSA-N
SMILES
CCOC(=O)C1=C(C)NC(=S)NC1C1=CC(O)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.24 | 100 | |
| Ethanol | 5.85 | 20 |
Preparing Stock Solutions
for Monastrol
The following data is based on the product molecular weight 292.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.10 mL | 34.21 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mayer Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 1999 PMID: 10542155
- Kapoor Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J.Cell Biol. 2000 PMID: 10973989
Product Specific Notices for Monastrol
For research use only
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