MOG (35-55)

Name: MOG (35-55)
Brand: Tocris Bioscience
SKU: 2568

Tocris Bioscience, part of Bio-Techne | Catalog # 2568

Citations (14)

COA / SDS

Encephalitogenic myelin oligodendrocyte glycoprotein fragment

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Product Description
Product Specifications
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Background References
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Key Product Details

Description

Encephalitogenic myelin oligodendrocyte glycoprotein fragment

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Product Description

MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.

Product Specifications

Molecular Weight

2581.97

Formula

C₁₁₈H₁₇₇N₃₅O₂₉S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

149635-73-4

PubChem ID

24868190

InChI Key

JMTCEFUSRHYJBF-DDJPMISGSA-N

SMILES

[H]N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.5mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Miyamura Myelin oligodendrocyte glycoprotein 35-55 (MOG 35-55)-induced experimental autoimmune encephalomyelitis: a model of chronic multiple sclerosis. Bio.Protoc. 2019 PMID: 33654948
Kenison Tolerogenic nanoparticles suppress central nervous system inflammation. Proc.Natl.Acad.Sci.U.S.A. 2020 PMID: 33239445
Slavin Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity 1998 PMID: 9771980
Zhang T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6xSJL) F1 mice. J.Neuroimmunol. 2004 PMID: 14975581
Ichikawa Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J.Immunol. 1996 PMID: 8752946