Modafinil

Name: Modafinil
Brand: Tocris Bioscience
SKU: 1811

Tocris Bioscience, part of Bio-Techne | Catalog # 1811

Citations (7)

COA / SDS

Psychostimulant

Key Product Details

Description:	Psychostimulant
Alternative Names:	CRL 40476
Chemical Name:	2-[(Diphenylmethyl)sulfinyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	273.35

View Full Technical Details for Modafinil

Technical Data
Citations

Biological Activity for Modafinil

Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

Technical Data for Modafinil

M. Wt	273.35
Formula	C₁₅H₁₅NO₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	68693-11-8
PubChem ID	4236
InChi Key	YFGHCGITMMYXAQ-UHFFFAOYSA-N
Smiles	O=S(CC(N)=O)C(C2=CC=CC=C2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Modafinil

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.5	75
	ethanol	2.73	10

Preparing Stock Solutions for Modafinil

The following data is based on the product molecular weight 273.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.88 mL	24.39 mL	48.78 mL
3.75 mM	0.98 mL	4.88 mL	9.76 mL
7.5 mM	0.49 mL	2.44 mL	4.88 mL
37.5 mM	0.10 mL	0.49 mL	0.98 mL

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Reconstitution Calculator

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References for Modafinil

References are publications that support the biological activity of the product.

Jenner Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 2000 PMID: 10968218
Madras Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 2006 PMID: 16885432
Ferraro Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 1997 PMID: 9426889