MNI-caged-NMDA is a NMDA (Cat.No. 0114) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Stoichiometrically releases chirally pure NMDA. Suitable for uncaging with 300-380 nm excitation. Improved localization can be achieved by uncaging at 405 nm (with mM concentration of caged compound in the bath solution). Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.

Licensing Information

Sold under license from the UK Medical Research Council

Product Specifications

Molecular Weight

323.30

Formula

C₁₄H₁₇N₃O₆

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

(R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid

CAS Number

1227675-52-6

PubChem ID

57369294

InChI Key

MUCRWOILMOHLGD-SECBINFHSA-N

SMILES

O=C(C[C@H](C(O)=O)NC)N2C1=C([N+]([O-])=O)C=CC(OC)=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.62	5 with gentle warming
	DMSO	32.33	100

Preparing Stock Solutions for MNI-caged-NMDA

The following data is based on the product molecular weight 323.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.47 mL	30.93 mL
5 mM	0.62 mL	3.09 mL	6.19 mL
10 mM	0.31 mL	1.55 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Background References

References are publications that support the biological activity of the product.

Palma-Cerda New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 2012 PMID: 22609535

MNI-caged-NMDA

Tocris Bioscience, part of Bio-Techne | Catalog # 2224

Key Product Details

Description

Alternative Names

View all Additional NMDA Receptor Compounds »

Product Description