MMPIP hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2963
Potent and selective negative allosteric modulator of mGlu7 receptors
Discontinued Product
2963 has been discontinued.
View all Group III mGluR Antagonists products.
Key Product Details
Description
Potent and selective negative allosteric modulator of mGlu7 receptors
Product Description
MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.Product Specifications
Molecular Weight
369.80
Formula
C19H15N3O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
CAS Number
1215566-78-1
PubChem ID
52974245
InChI Key
HXHQNERSIJXMTQ-UHFFFAOYSA-N
SMILES
O=C1N(C)C(C3=CC=C(OC)C=C3)=CC2=C1C(C4=CC=NC=C4)=NO2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.7 | 10 |
Preparing Stock Solutions
for MMPIP hydrochloride
The following data is based on the product molecular weight 369.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.04 mL | 135.21 mL | 270.42 mL |
| 0.5 mM | 5.41 mL | 27.04 mL | 54.08 mL |
| 1 mM | 2.70 mL | 13.52 mL | 27.04 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Suzuki In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 2007 PMID: 17609420
Product Specific Notices for MMPIP hydrochloride
For research use only
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