MMG 11
Tocris Bioscience, part of Bio-Techne | Catalog # 6858
TLR2 antagonist
Product Description
MMG 11 is a TLR2 antagonist (IC50 values are in the range 1.7 - 5.7 μM). Exhibits selectivity for TLR2 over TLR4, TLR5, TLR7/8 and TLR9. Reduces TLR2-mediated cytokine secretion from PBMCs. MMG 11 preferentially inhibits TLR2/1- over TLR2/6-mediated NK-κB activation (IC50 values are 0.87 and 7.4 μM, respectively).Product Specifications
Molecular Weight
306.27
Formula
C15H14O7
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
CAS Number
313254-94-3
PubChem ID
854609
InChI Key
IIDUJWIVMGALOG-UHFFFAOYSA-N
SMILES
CCOC(=O)C1=CC=C(CC(=O)C2=C(O)C(O)=C(O)C=C2)O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.63 | 100 | |
| Ethanol | 15.31 | 50 |
Preparing Stock Solutions
for MMG 11
The following data is based on the product molecular weight 306.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.27 mL | 16.33 mL | 32.65 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Grabowski The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem.Pharmacol. 2020 PMID: 31678495
- Grabowski Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem.Pharmacol. 2019 PMID: 29684378
Product Specific Notices for MMG 11
For research use only
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