MLS 1547
Tocris Bioscience, part of Bio-Techne | Catalog # 6171
G protein-biased D2 partial agonist
Key Product Details
Description
G protein-biased D2 partial agonist
Product Description
MLS 1547 is a G protein-biased D2 receptor partial agonist (Ki = 1.2 μM). Stimulates D2 receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D2 receptors.Product Specifications
Molecular Weight
354.83
Formula
C19H19ClN4O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol
CAS Number
315698-36-3
PubChem ID
1093278
InChI Key
OPEJNANYABTIGC-UHFFFAOYSA-N
SMILES
OC1=C(C=C(C2=C1N=CC=C2)Cl)CN3CCN(C4=CC=CC=N4)CC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.48 | 100 |
Preparing Stock Solutions
for MLS 1547
The following data is based on the product molecular weight 354.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.09 mL | 28.18 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Free Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 DA receptor. Mol.Pharmacol. 2014 PMID: 24755247
Product Specific Notices for MLS 1547
For research use only
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