MLCK inhibitor peptide 18
Tocris Bioscience, part of Bio-Techne | Catalog # 1885
Selective inhibitor of myosin light chain kinase
Key Product Details
Description
Selective inhibitor of myosin light chain kinase
Alternative Names
Myosin Light Chain Kinase Inhibitor Peptide 18
Product Description
MLCK inhibitor peptide 18 is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.Product Specifications
Molecular Weight
1324.64
Formula
C60H105N23O11
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
224579-74-2
PubChem ID
10102940
InChI Key
JPOKAKNGULMYHZ-UILVTTEASA-N
SMILES
[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Zolotarevsky A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 2002 PMID: 12105845
- Lukas Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 1999 PMID: 10072688
Product Specific Notices for MLCK inhibitor peptide 18
For research use only
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