ML 9 hydrochloride

Name: ML 9 hydrochloride
Brand: Tocris Bioscience
SKU: 0431

Tocris Bioscience, part of Bio-Techne | Catalog # 0431

Citations (3)

COA / SDS

Myosin light chain kinase inhibitor

Key Product Details

Description:	Myosin light chain kinase inhibitor
Chemical Name:	1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	361.29

View Full Technical Details for ML 9 hydrochloride

Technical Data
Citations

Biological Activity for ML 9 hydrochloride

ML 9 hydrochloride is a selective MLCK inhibitor (K_i values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca²⁺ entry (SOCE).

Compound Libraries for ML 9 hydrochloride

ML 9 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 9 hydrochloride

M. Wt	361.29
Formula	C₁₅H₁₇ClN₂O₂S.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	105637-50-1
PubChem ID	108047
InChi Key	ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Smiles	Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 9 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.03	25

Preparing Stock Solutions for ML 9 hydrochloride

The following data is based on the product molecular weight 361.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.07 mL	55.36 mL	110.71 mL
1.25 mM	2.21 mL	11.07 mL	22.14 mL
2.5 mM	1.11 mL	5.54 mL	11.07 mL
12.5 mM	0.22 mL	1.11 mL	2.21 mL

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References for ML 9 hydrochloride

References are publications that support the biological activity of the product.

Hidaka and Hagiwara Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci.
Seto Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 1991 PMID: 1874276
Varnai STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 2009 PMID: 19187978
Hidaka and Koybashi Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 1992 PMID: 1605572