ML 354

Name: ML 354
Brand: Tocris Bioscience
SKU: 5387

Tocris Bioscience, part of Bio-Techne | Catalog # 5387

Citations (5)

COA / SDS

Selective PAR4 antagonist

Discontinued Product

5387 has been discontinued. View all Protease-Activated Receptor Antagonists products.

Key Product Details

Description:	Selective PAR₄ antagonist
Chemical Name:	1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
Purity:	≥98% (HPLC)
Molecular Weight:	282.29

View Full Technical Details for ML 354

Technical Data
Citations

Biological Activity for ML 354

ML 354 is a selective PAR₄ antagonist (IC₅₀ = 140 nM). Exhibits 70-fold selectivity for PAR₄ over PAR₁.

Technical Data for ML 354

M. Wt	282.29
Formula	C₁₆H₁₄N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	89159-60-4
PubChem ID	752812
InChi Key	GNJUKVGDCUKDLF-UHFFFAOYSA-N
Smiles	CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ML 354

References are publications that support the biological activity of the product.

Wen Substituted indoles as selective protease activated receptor 4 (PAR₄) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 2014 PMID: 25176330

ML 354

Tocris Bioscience, part of Bio-Techne | Catalog # 5387

Key Product Details

Biological Activity for ML 354

Technical Data for ML 354

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ML 354

Product Documents for ML 354

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected