ML 347
Tocris Bioscience, part of Bio-Techne | Catalog # 4945
Potent and selective ALK1 and ALK2 inhibitor
Key Product Details
Description
Potent and selective ALK1 and ALK2 inhibitor
Alternative Names
LDN 193719,1lWY,VU0469381
Product Description
ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).Product Specifications
Molecular Weight
352.39
Formula
C22H16N4O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
CAS Number
1062368-49-3
PubChem ID
44577753
InChI Key
FVRYPYDPKSZGNS-UHFFFAOYSA-N
SMILES
COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.05 | 20 |
Preparing Stock Solutions
for ML 347
The following data is based on the product molecular weight 352.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.19 mL | 70.94 mL | 141.89 mL |
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 2 mM | 1.42 mL | 7.09 mL | 14.19 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Engers Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 2013 PMID: 23639540
Product Specific Notices for ML 347
For research use only
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