ML 3403

Name: ML 3403
Brand: Tocris Bioscience
SKU: 4586

Tocris Bioscience, part of Bio-Techne | Catalog # 4586

COA / SDS

p38 inhibitor

Discontinued Product

4586 has been discontinued. View all p38 Inhibitors products.

Key Product Details

Description:	p38 inhibitor
Chemical Name:	[5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine
Purity:	≥98% (HPLC)
Molecular Weight:	404.5

View Full Technical Details for ML 3403

Technical Data
Citations

Biological Activity for ML 3403

ML 3403 is a p38 MAPK inhibitor (IC₅₀ = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC₅₀ values are 0.039 and 0.16 μM respectively).

Compound Libraries for ML 3403

ML 3403 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 3403

M. Wt	404.5
Formula	C₂₃H₂₁FN₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	549505-65-9
PubChem ID	6419739
InChi Key	VXPWQNBKEIVYIS-UHFFFAOYSA-N
Smiles	FC(C=C3)=CC=C3C(N=C(SC)N2)=C2C1=CC=NC(NC(C)C4=CC=CC=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ML 3403

References are publications that support the biological activity of the product.

Kammerer Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab.Dispos. 2007 PMID: 17344341
Laufer Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J.Med.Chem. 2003 PMID: 12852754