ML 315 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5700

Inhibitor of Clk and DYRK kinases
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Key Product Details

Description

Inhibitor of Clk and DYRK kinases

View all Cdc2-like Kinase Inhibitors »

Product Description

ML 315 hydrochloride is a inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC50 values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

Product Specifications

Molecular Weight

410.68

Formula

C18H13Cl2N3O2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride

CAS Number

1440251-53-5

PubChem ID

127021037

InChI Key

MNCDEAAKKQCKSX-UHFFFAOYSA-N

SMILES

ClC1=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=CC(Cl)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.42 100
Ethanol 18.71 50

Preparing Stock Solutions for ML 315 hydrochloride

The following data is based on the product molecular weight 410.68

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.17 mL 24.35 mL
5 mM 0.49 mL 2.43 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 315 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 315 hydrochloride

For research use only

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