ML 281
Tocris Bioscience, part of Bio-Techne | Catalog # 4880
STK33 inhibitor
Product Description
ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.Product Specifications
Molecular Weight
389.47
Formula
C22H19N3O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
CAS Number
1404437-62-2
PubChem ID
53377448
InChI Key
HWOYIOLMBQSTQS-UHFFFAOYSA-N
SMILES
CC(C)C1=CC(C2=NC(C=CC=C3)=C3NC2=O)=C(NC(C4=CC=CS4)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.95 | 100 |
Preparing Stock Solutions
for ML 281
The following data is based on the product molecular weight 389.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Weiwer A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells. ACS Med.Chem.Lett. 2012 PMID: 23256033
Product Specific Notices for ML 281
For research use only
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