ML 252

Name: ML 252
Brand: Tocris Bioscience
SKU: 4687

Tocris Bioscience, part of Bio-Techne | Catalog # 4687

COA / SDS

Potent and selective KV7.2 inhibitor; brain penetrant

Key Product Details

Description:	Potent and selective K_V7.2 inhibitor; brain penetrant
Chemical Name:	(S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
Purity:	≥98% (HPLC)
Molecular Weight:	308.43

View Full Technical Details for ML 252

Technical Data
Citations

Biological Activity for ML 252

ML 252 is a potent and selective inhibitor of K_V7.2 voltage-gated potassium channels (IC₅₀ = 70 nM), which displays >40-fold selectivity for K_V7.2 over K_V7.1 channels (IC₅₀ = 2.9 μM for K_V7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC₅₀ values are 944 and 160 nM, respectively). ML 252 displays selectivity for K_V7.2 over a panel of >68 GPCRs, ion channels and transporters; inhibits melatonin MT₁ receptor 60% at 10 μM. ML 252 is brain penetrant.

Compound Libraries for ML 252

ML 252 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 252

M. Wt	308.43
Formula	C₂₀H₂₄N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1392494-64-2
PubChem ID	26873419
InChi Key	FROGGFONBYACJB-UHFFFAOYSA-N
Smiles	O=C([C@@H](CC)C1=CC=CC=C1)NC2=C(N3CCCC3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 252

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.84	100
	ethanol	30.84	100

Preparing Stock Solutions for ML 252

The following data is based on the product molecular weight 308.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.21 mL	32.42 mL
5 mM	0.65 mL	3.24 mL	6.48 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References for ML 252

References are publications that support the biological activity of the product.

Cheung Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K_V7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phe J.Med.Chem. 2012 PMID: 22793372