ML 240

Tocris Bioscience, part of Bio-Techne | Catalog # 5153

ATP-competitive inhibitor of p97 ATPase
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Key Product Details

Description

ATP-competitive inhibitor of p97 ATPase

View all Other ER Stress/UPR Inhibitors »

Product Description

ML 240 is an ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

Product Specifications

Molecular Weight

396.44

Formula

C23H20N6O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine

CAS Number

1346527-98-7

PubChem ID

49830258

InChI Key

NHAMBLRUUJAFOY-UHFFFAOYSA-N

SMILES

NC1=NC4=C(C=CC=C4)N1C3=NC2=C(OC)C=CC=C2C(NCC5=CC=CC=C5)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.93 20

Preparing Stock Solutions for ML 240

The following data is based on the product molecular weight 396.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.61 mL 63.06 mL 126.12 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
2 mM 1.26 mL 6.31 mL 12.61 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 240

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 240

For research use only

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