ML 233

Tocris Bioscience, part of Bio-Techne | Catalog # 5966

COA / SDS

Non-peptide apelin agonist

Key Product Details

Description:	Non-peptide apelin agonist
Chemical Name:	(E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	359.44

View Full Technical Details for ML 233

Technical Data
Citations

Biological Activity for ML 233

ML 233 is a non-peptide apelin receptor agonist (EC₅₀ = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC₅₀ = >79 μM).

Technical Data for ML 233

M. Wt	359.44
Formula	C₁₉H₂₁NO₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2080311-92-6
PubChem ID	60138111
InChi Key	RSMZOLWJZGIWOV-CZIZESTLSA-N
Smiles	CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 233

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.97	50

Preparing Stock Solutions for ML 233

The following data is based on the product molecular weight 359.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.56 mL	27.82 mL	55.64 mL
2.5 mM	1.11 mL	5.56 mL	11.13 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

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Reconstitution Calculator

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References for ML 233

References are publications that support the biological activity of the product.

Khan Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program 2011 PMID: 22834038
Yang Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 2015 PMID: 26143239