ML 133 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4549
Kir2 channel blocker
Key Product Details
Description
Kir2 channel blocker
Product Description
ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).Product Specifications
Molecular Weight
313.82
Formula
C19H19NO.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
CAS Number
1222781-70-5
PubChem ID
44247466
InChI Key
NGQIBUUFXDPHKT-UHFFFAOYSA-N
SMILES
COC(C=C3)=CC=C3CNCC1=C(C=CC=C2)C2=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.38 | 100 |
Preparing Stock Solutions
for ML 133 hydrochloride
The following data is based on the product molecular weight 313.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.19 mL | 15.93 mL | 31.87 mL |
| 5 mM | 0.64 mL | 3.19 mL | 6.37 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.19 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wu A potent and selective small molecule Kir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro 2010 PMID: 21433384
- Wang Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 2011 PMID: 21615117
Product Specific Notices for ML 133 hydrochloride
For research use only
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