ML 00253764 hydrochloride

Name: ML 00253764 hydrochloride
Brand: Tocris Bioscience
SKU: 4854

Tocris Bioscience, part of Bio-Techne | Catalog # 4854

Citations (3)

COA / SDS

Melanocortin MC4 receptor antagonist; brain penetrant

Key Product Details

Description:	Melanocortin MC₄ receptor antagonist; brain penetrant
Chemical Name:	2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	413.71

View Full Technical Details for ML 00253764 hydrochloride

Technical Data
Citations

Biological Activity for ML 00253764 hydrochloride

ML 00253764 hydrochloride is a non-peptide, melanocortin MC₄ receptor antagonist (IC₅₀ values are 320, 810 and 2120 nM for MC₄, MC₃ and MC₅ receptors respectively). Decreases cAMP accumulation in HEK-293 cells expressing the MC₄ receptor. Increases food intake and reduces loss of lean body mass in tumor bearing mice. Brain penetrant.

Compound Libraries for ML 00253764 hydrochloride

ML 00253764 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 00253764 hydrochloride

M. Wt	413.71
Formula	C₁₈H₁₈BrFN₂O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1706524-94-8
PubChem ID	90488979
InChi Key	KZUMGPQDDCBFBF-UHFFFAOYSA-N
Smiles	BrC1=CC(CCC2=C(F)C=CC=C2C3=NCCN3)=C(OC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 00253764 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.14	10
	DMSO	41.37	100

Preparing Stock Solutions for ML 00253764 hydrochloride

The following data is based on the product molecular weight 413.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.17 mL
5 mM	0.48 mL	2.42 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for ML 00253764 hydrochloride

References are publications that support the biological activity of the product.

Vos Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J.Med.Chem. 2004 PMID: 15027849
Tucci Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines. Bioorg.Med.Chem.Lett. 2005 PMID: 16098742
Nicholson Peripheral administration of a melanocortin 4-receptor inverse agonist prevents loss of lean body mass in tumor-bearing mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16436498