MK 886
Tocris Bioscience, part of Bio-Techne | Catalog # 1311
Inhibitor of 5-lipoxygenase-activating protein (FLAP)
Key Product Details
Description
Inhibitor of 5-lipoxygenase-activating protein (FLAP)
Alternative Names
L-663,536
Product Description
MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Also moderately potent PPARα antagonist (IC50 = 0.5-1 μM). Orally active in vivo.Product Specifications
Molecular Weight
472.08
Formula
C27H34ClNO2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid
CAS Number
118414-82-7
PubChem ID
3651377
InChI Key
QAOAOVKBIIKRNL-UHFFFAOYSA-N
SMILES
ClC(C=C3)=CC=C3CN(C(CC(C)(C(O)=O)C)=C2SC(C)(C)C)C1=C2C=C(C(C)C)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.21 | 100 | |
| Ethanol | 2.36 | 5 |
Preparing Stock Solutions
for MK 886
The following data is based on the product molecular weight 472.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.59 mL | 21.18 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mancini 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol.Pharmacol. 1992 PMID: 1538707
- Gillard L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can.J.Physiol.Pharmacol. 1989 PMID: 2548691
- Kehrer Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886. Biochem.J. 2001 PMID: 11389700
- Dixon Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 1990 PMID: 2300173
Product Specific Notices for MK 886
For research use only
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