Mitochondrial fusion promoter M1

Name: Mitochondrial fusion promoter M1
Brand: Tocris Bioscience
SKU: 6898

Tocris Bioscience, part of Bio-Techne | Catalog # 6898

COA / SDS

Mitochondrial fusion promoter

Discontinued Product

6898 has been discontinued. View all Compounds for Mitochondrial Dynamics products.

Key Product Details

Description:	Mitochondrial fusion promoter
Chemical Name:	4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
Purity:	≥98% (HPLC)
Molecular Weight:	364.05

View Full Technical Details for Mitochondrial fusion promoter M1

Technical Data
Citations

Biological Activity for Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial fusion promoter. Protects cells from mitochondrial fragmentation-associated cell death. Induces mitochondrial fusion in effector T cells imposing a memory T cell morphology. Improves cellular respiration and potentiates glucose-stimulated insulin-secretion in cholesterol-exposed pancreatic β cells. Mitochondrial fusion promoter M1 also enhances mitochondrial dynamics and transport velocity in axons of the sciatic nerve in vitro and enhances axon regeneration in the optic nerve in an in vivo model of nerve damage.

Technical Data for Mitochondrial fusion promoter M1

M. Wt	364.05
Formula	C₁₄H₁₀Cl₄N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	219315-22-7
PubChem ID	136672588
InChi Key	CYVDGZYJHHYIIU-GXHLCREISA-N
Smiles	C\C(=N/NC1=C(Cl)C=C(Cl)C=C1Cl)C1=C(O)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Mitochondrial fusion promoter M1

References are publications that support the biological activity of the product.

Au A small molecule M1 promotes optic nerve regeneration to restore target-specific neural activity and visual function. Proc.Natl.Acad.Sci.USA 2022 PMID: 36306327
Wang A small molecule promotes mitochondrial fusion in mammalian cells. Angew.Chem.Int.Ed.Engl. 2012 PMID: 22907892
Buck Mitochondrial dynamics controls T cell fate through metabolic programming. Cell 2016 PMID: 27293185
Asalla Restoring mitochondrial function: a small molecule-mediated approach to enhance glucose stimulated insulin secretion in cholesterol accumulated pancreatic beta cells. Sci.Rep. 2016 PMID: 27282931

Mitochondrial fusion promoter M1

Tocris Bioscience, part of Bio-Techne | Catalog # 6898

Key Product Details

Biological Activity for Mitochondrial fusion promoter M1

Technical Data for Mitochondrial fusion promoter M1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Mitochondrial fusion promoter M1

Product Documents for Mitochondrial fusion promoter M1

COA

Certificate of Analysis

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