Mithramycin A
Tocris Bioscience, part of Bio-Techne | Catalog # 1489
Inhibitor of DNA and RNA polymerase
Key Product Details
Description
Inhibitor of DNA and RNA polymerase
Product Description
Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.Product Specifications
Molecular Weight
1085.16
Formula
C52H76O24
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
CAS Number
18378-89-7
PubChem ID
90479798
InChI Key
CFCUWKMKBJTWLW-YZCDWGPJSA-N
SMILES
OC1=C2C(C=C3C(C([C@@H](OC5OC(C)C(O)C(OC6OC(C)C(O)C(OC7OC(C)C(O)C(O)(C)C7)C6)C5)[C@@]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)([H])C3)=O)=C2O)=CC(O[C@@H]4OC(C)C(O)C(OC8OC(C)C(O)C(O)C8)C4)=C1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.26 | 50 |
Preparing Stock Solutions
for Mithramycin A
The following data is based on the product molecular weight 1085.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.84 mL | 9.22 mL | 18.43 mL |
| 2.5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 25 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miller Mithramycin selectively inhibits transcription of G-C containing DNA. Am.J.Med.Sci. 1987 PMID: 2962490
- Ray Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene. Am.J.Med.Sci. 1990 PMID: 2147360
- Demicheli and Garnier-Suillerot Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion. Biochem.Biophys.Res.Commun. 1991 PMID: 1828342
Product Specific Notices for Mithramycin A
For research use only
⚠ WARNING: This product can expose you to chemicals including Plicamycin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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