Miro1 Reducer
Tocris Bioscience, part of Bio-Techne | Catalog # 7091
Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
Key Product Details
Description
Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
Product Description
Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.Product Specifications
Molecular Weight
425.85
Formula
C20H16FN7O.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
CAS Number
2624336-91-8
InChI Key
UKXRHSHXZHFFTA-UHFFFAOYSA-N
SMILES
FC1=CC=CC(NC(NC2=CC=C(C=C2)NC3=CC(N4C=CN=C4)=NC=N3)=O)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.58 | 100 |
Preparing Stock Solutions
for Miro1 Reducer
The following data is based on the product molecular weight 425.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.74 mL | 23.48 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.70 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hsieh Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models. Cell Metab. 2019 PMID: 31564441
Product Specific Notices for Miro1 Reducer
For research use only
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