Miro1 Reducer

Name: Miro1 Reducer
Brand: Tocris Bioscience
SKU: 7091

Tocris Bioscience, part of Bio-Techne | Catalog # 7091

Citations (4)

COA / SDS

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

Key Product Details

Description:	Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
Chemical Name:	N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	425.85

View Full Technical Details for Miro1 Reducer

Technical Data
Citations

Biological Activity for Miro1 Reducer

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC₅₀ = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Compound Libraries for Miro1 Reducer

Miro1 Reducer is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Miro1 Reducer

M. Wt	425.85
Formula	C₂₀H₁₆FN₇O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2624336-91-8
InChi Key	UKXRHSHXZHFFTA-UHFFFAOYSA-N
Smiles	FC1=CC=CC(NC(NC2=CC=C(C=C2)NC3=CC(N4C=CN=C4)=NC=N3)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Miro1 Reducer

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.58	100

Preparing Stock Solutions for Miro1 Reducer

The following data is based on the product molecular weight 425.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.74 mL	23.48 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for Miro1 Reducer

References are publications that support the biological activity of the product.

Hsieh Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models. Cell Metab. 2019 PMID: 31564441