MIRA-1

Tocris Bioscience, part of Bio-Techne | Catalog # 3362

Restores mutant p53 activity; proapoptotic
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Key Product Details

Description

Restores mutant p53 activity; proapoptotic

View all Additional p53-related Compounds »

Product Description

MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

Product Specifications

Molecular Weight

183.16

Formula

C8H9NO4

Storage

Store at +4°C

Chemical Name

1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione

CAS Number

72835-26-8

PubChem ID

227681

InChI Key

YXEWPGYLMHXLPS-UHFFFAOYSA-N

SMILES

O=C(N1COC(CC)=O)C=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.32 100
Ethanol 18.32 100

Preparing Stock Solutions for MIRA-1

The following data is based on the product molecular weight 183.16

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.46 mL 27.30 mL 54.60 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
10 mM 0.55 mL 2.73 mL 5.46 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MIRA-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MIRA-1

For research use only

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