(-)-MK 801 maleate

Name: (-)-MK 801 maleate
Brand: Tocris Bioscience
SKU: 0955

Tocris Bioscience, part of Bio-Techne | Catalog # 0955

Citations (83)

COA / SDS

NMDA antagonist; less active enantiomer of (+)-MK 801

Key Product Details

Description:	NMDA antagonist; less active enantiomer of (+)-MK 801
Chemical Name:	(5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Purity:	≥98% (HPLC)
Molecular Weight:	337.37

View Full Technical Details for (-)-MK 801 maleate

Technical Data
Citations

Biological Activity for (-)-MK 801 maleate

(-)-MK 801 maleate is a less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate.

(+)-enantiomer also available.

Compound Libraries for (-)-MK 801 maleate

(-)-MK 801 maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (-)-MK 801 maleate

M. Wt	337.37
Formula	C₁₆H₁₅N.C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	121917-57-5
PubChem ID	16219612
InChi Key	QLTXKCWMEZIHBJ-FWHYOZOBSA-N
Smiles	O=C(O)/C=C\C(O)=O.C[C@@]14C3=C(C=CC=C3)C[C@H](N4)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-MK 801 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.43	25 with gentle warming
	DMSO	33.74	100

Preparing Stock Solutions for (-)-MK 801 maleate

The following data is based on the product molecular weight 337.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for (-)-MK 801 maleate

References are publications that support the biological activity of the product.

Thompson Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-MthD.-aspartate antagonists. J.Med.Chem. 1990 PMID: 1688947
Genovese and Lu Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology. 1991 PMID: 1771215