(-)-Cannabidiol

Name: (-)-Cannabidiol
Brand: Tocris Bioscience
SKU: 1570

Tocris Bioscience, part of Bio-Techne | Catalog # 1570

Citations (85)

COA / SDS

Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor

Key Product Details

Description:	Natural cannabinoid; GPR55 antagonist, weak CB₁ antagonist, CB₂ inverse agonist and AMT inhibitor
Alternative Names:	CBD
Chemical Name:	2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
Purity:	≥98% (HPLC)
Molecular Weight:	314.47

View Full Technical Details for (-)-Cannabidiol

Technical Data
Citations

Biological Activity for (-)-Cannabidiol

(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB₁ antagonist (IC₅₀ values are 0.445 and 3.35 μM), CB₂ receptor inverse agonist and inhibitor of anandamide uptake (IC₅₀ = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC₅₀ = 3.5 μM). Reduces inflammation and LPS-induced cytokine production in cultured microglial cells.

Technical Data for (-)-Cannabidiol

M. Wt	314.47
Formula	C₂₁H₃₀O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	13956-29-1
PubChem ID	12302390
InChi Key	QHMBSVQNZZTUGM-ROUUACIJSA-N
Smiles	CCCCCC1=CC(O)=C([C@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Cannabidiol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	23.59	75
	DMSO	23.59	75

Preparing Stock Solutions for (-)-Cannabidiol

The following data is based on the product molecular weight 314.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.24 mL	21.20 mL	42.40 mL
3.75 mM	0.85 mL	4.24 mL	8.48 mL
7.5 mM	0.42 mL	2.12 mL	4.24 mL
37.5 mM	0.08 mL	0.42 mL	0.85 mL

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References for (-)-Cannabidiol

References are publications that support the biological activity of the product.

Dos-Santos-Pereira Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-?B-dependent signaling and glucose consumption. Glia 2020 PMID: 31647138
Deutsch A personal retrospective: Elevating Anandamide (AEA) by targeting fatty acid amide hydrolase (FAAH) and the fatty acid binding proteins (FABPs). Front.Pharmacol. 2016 PMID: 27790143
Thomas Cannabidiol displays unexpectedly high potency as an antagonist of CB₁ and CB₂ receptor agonists in vitro. Br.J.Pharmacol. 2007 PMID: 17245363
Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
Petitet Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of Δ⁹-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci. 1998 PMID: 9667767
Costa Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br.J.Pharmacol. 2004 PMID: 15313881