(-)-Cannabidiol

Tocris Bioscience, part of Bio-Techne | Catalog # 1570

Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
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Key Product Details

Description

Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor

Alternative Names

CBD

View all Non-selective Cannabinoid Receptor Antagonists »

Product Description

(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC50 = 3.5 μM). Reduces inflammation and LPS-induced cytokine production in cultured microglial cells.

Product Specifications

Molecular Weight

314.47

Formula

C21H30O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

CAS Number

13956-29-1

PubChem ID

12302390

InChI Key

QHMBSVQNZZTUGM-ROUUACIJSA-N

SMILES

CCCCCC1=CC(O)=C([C@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.59 75
Ethanol 23.59 75

Preparing Stock Solutions for (-)-Cannabidiol

The following data is based on the product molecular weight 314.47

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.24 mL 21.20 mL 42.40 mL
3.75 mM 0.85 mL 4.24 mL 8.48 mL
7.5 mM 0.42 mL 2.12 mL 4.24 mL
37.5 mM 0.08 mL 0.42 mL 0.85 mL

Calculators

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Reconstitution Calculator

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Product Documents for (-)-Cannabidiol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (-)-Cannabidiol

For research use only

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