MIM1

Name: MIM1
Brand: Tocris Bioscience
SKU: 4762

Tocris Bioscience, part of Bio-Techne | Catalog # 4762

Citations (10)

COA / SDS

Mcl-1 inhibitor; proapoptotic

Discontinued Product

4762 has been discontinued. View all Bcl-2 Family Inhibitors products.

Key Product Details

Description:	Mcl-1 inhibitor; proapoptotic
Chemical Name:	4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol
Molecular Weight:	347.43

View Full Technical Details for MIM1

Technical Data
Citations

Biological Activity for MIM1

MIM1 is an inhibitor of Mcl-1. Inhibits Mcl-1 indirectly by induction of the proapoptotic Mcl-1 ligand NOXA via the unfolded protein response (UPR) pathway. Sensitizes leukemia cells to the Bcl-2 inhibitor venetoclax (ABT-199). Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.

Technical Data for MIM1

M. Wt	347.43
Formula	C₁₇H₂₁N₃O₃S
Storage	Store at +4°C
PubChem ID	135875424
InChi Key	RGGFUBMUOVFZEF-DLHVAJNCSA-N
Smiles	CC2=CS/C(N2/N=C/C3=CC=C(O)C(O)=C3O)=N\C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MIM1

References are publications that support the biological activity of the product.

Mallick Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. Cell Death Dis. 2019 PMID: 30796196
Cohen A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 2012 PMID: 22999885

MIM1

Tocris Bioscience, part of Bio-Techne | Catalog # 4762

Key Product Details

Biological Activity for MIM1

Technical Data for MIM1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for MIM1

Product Documents for MIM1

COA

Certificate of Analysis

SDS

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