Miglustat hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3117
α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity
Key Product Details
Description
α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity
Alternative Names
N-Butyldeoxynojirimycin hydrochloride,NB-DNJ
Product Description
Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.Product Specifications
Molecular Weight
255.74
Formula
C10H21NO4.HCl
Storage
Desiccate at -20°C
Chemical Name
(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
CAS Number
210110-90-0
PubChem ID
657399
InChI Key
QPAFAUYWVZMWPR-ZSOUGHPYSA-N
SMILES
CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.18 | 75 | |
| DMSO | 19.18 | 75 |
Preparing Stock Solutions
for Miglustat hydrochloride
The following data is based on the product molecular weight 255.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 5.21 mL | 26.07 mL | 52.14 mL |
| 3.75 mM | 1.04 mL | 5.21 mL | 10.43 mL |
| 7.5 mM | 0.52 mL | 2.61 mL | 5.21 mL |
| 37.5 mM | 0.10 mL | 0.52 mL | 1.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dwek Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 2002 PMID: 12119611
- Noel Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharmacol.Exp.Ther. 2008 PMID: 18309088
- Platt N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 1994 PMID: 8132559
Product Specific Notices for Miglustat hydrochloride
For research use only
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